By Dermatology + Plastic Surgery | March 2026
Patients are asking about newer skin tightening technologies, including XERF. Here’s what we found.
At Dermatology + Plastic Surgery, we believe our patients deserve more than buzz. Before we recommend any treatment, we ask the boring-but-important questions: What is this device actually cleared to do by the FDA? Is there peer-reviewed data? And is there real evidence it works?
| Category | Ultrasound-Based (e.g., Sofwave SUPERB™) | Newer RF Devices (e.g., XERF) | Laser-Based Skin Tightening |
| What it is | Fractional ultrasound | Radiofrequency (varies by device) | Laser-based energy |
| FDA cleared for | Multiple aesthetic indications (e.g., lifting, wrinkles) | Varies by device (some non-aesthetic indications) | Skin tightening and dermal remodeling |
| Published studies | 40+ peer-reviewed | Limited or none publicly available (varies by device) | Established body of clinical literature |
| Collagen increase | Biopsy-confirmed increase reported | Limited published data | Clinical improvement supported by studies |
| Elastin increase | Biopsy-confirmed increase reported | Limited published data | Limited histologic data available |
| Mechanism | Targets mid-dermis with controlled thermal zones | Bulk heating depending on settings | Dermal heating via light-based energy |
| Fat loss risk | Established safety profile with no reported fat atrophy in large datasets | Long-term safety data still developing | Generally low when used appropriately |
| Results last | 12+ months reported | Not yet well established | Varies by device and protocol |
| Time on market | Several years of clinical use | Newer to market | 10+ years of clinical use |
Sources: Wat et al., Lasers in Surgery and Medicine, 2022 (collagen/elastin data); Sofwave Medical clinical data on file; full publication library at sofwave.com/clinical-evidence.
FDA clearances are not marketing claims. They reflect the evidence the agency has reviewed for each intended use.
As with any device, it’s important to understand the specific indication a technology is cleared for and how that aligns with its intended use in an aesthetic setting.
Sofwave has over 40 peer-reviewed publications. Critically, it has biopsy data, meaning researchers took actual tissue samples and measured changes under a microscope. The findings: a 68% increase in collagen and a 33% increase in elastin after a single treatment (Wat et al., Lasers in Surgery and Medicine, 2022).
As of 3.23.26, there is limited publicly available peer-reviewed data for XERF. That doesn’t mean it cannot produce results. It means those results have not yet been demonstrated through independent, peer-reviewed research.
Think of it like cooking: to actually change the structure of something, you need to reach the right temperature. Too low and nothing really transforms; you get a surface effect that fades. Current research suggests collagen remodeling occurs around 65°C.
Sofwave is engineered to hit that sweet spot, 65–70°C, with built-in cooling to protect the skin’s surface. Most patients describe the sensation as warm but manageable.
Some RF technologies, including certain XERF protocols, may operate at lower temperatures in the 40–60°C range, which may not be sufficient to trigger meaningful structural collagen change.
Across skin tightening technologies, preserving facial fat is an important consideration, particularly around the jawline, cheeks, and neck.
Sofwave’s record here is clean: zero reported fat atrophy events across more than 667,000 treatments. That’s a meaningful benchmark for any patient considering a facial energy treatment.
Newer technologies are still building long-term safety data. Patients should ask how a treatment interacts with both their skin and the underlying tissue when deciding what’s right for them.
We encourage every patient, whether they’re considering Sofwave, XERF, or any other treatment, to ask these five questions:
Ask for the specific clearance language, not the marketing summary.
If your provider can’t name a number, that tells you something important.
Histology separates proof from promise faster than anything else.
Confident providers give you a documented timeline. Vague ones change the subject.
Especially relevant for treatments near the jawline, cheeks, and submental area.
At Dermatology + Plastic Surgery, we offer Sofwave because the evidence standard meets the bar we’ve set for every treatment we provide.
Treatments are typically completed in 30–45 minutes. Most patients return to their normal routine immediately, and results build gradually over 3 to 6 months as new collagen forms, with effects lasting 12 months or more.
We’d love to answer your questions in person.
Disclaimer: This content is for informational purposes only and does not constitute medical advice. Individual results vary. Consult a qualified provider to determine which treatments are appropriate for your specific needs.
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